Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil

PLoS One. 2019 Jun 11;14(6):e0217871. doi: 10.1371/journal.pone.0217871. eCollection 2019.

Abstract

The emergence of chikungunya virus (CHIKV) has raised serious concerns due to the virus' rapid dissemination into new geographic areas and the clinical features associated with infection. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. Our phylogenetic reconstructions indicated the circulation of the East-Central-South-African (ECSA) lineage in Rio de Janeiro. Time-measured phylogenetic analysis combined with CHIKV notified case numbers revealed the ECSA lineage was introduced in Rio de Janeiro around June 2015 (95% Bayesian credible interval: May to July 2015) indicating the virus was circulating unnoticed for 5 months before the first reports of CHIKV autochthonous transmissions in Rio de Janeiro, in November 2015. These findings reinforce that continued genomic surveillance strategies are needed to assist in the monitoring and understanding of arbovirus epidemics, which might help to attenuate public health impact of infectious diseases.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Africa / epidemiology
  • Brazil / epidemiology
  • Chikungunya Fever / epidemiology
  • Chikungunya Fever / genetics*
  • Chikungunya Fever / transmission
  • Chikungunya virus / genetics*
  • Female
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Male
  • Middle Aged
  • Phylogeny*

Associated data

  • figshare/10.6084/m9.figshare.8192237

Grants and funding

This research was funded by CNPq grant number (440685/2016-8); CAPES grant number (88887.130716/2016-00). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro /Faperj over the grant number E-26/202.930/2016 and by the Coordenação de Vigilância em Saúde e Laboratórios de Referência da Fundação Oswaldo Cruz.