Abstract
CRISPR/Cas9 genomic editing of wild-type hematopoietic stem cells generates Npm1-Alk, leading to ALK+ large-cell lymphomas in recipients.
CD30+ postthymic T-cell lymphomas are polyclonal but transplantable to secondary recipients with long latency.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Anaplastic Lymphoma Kinase / metabolism
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Animals
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Bone Marrow / virology
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Cell Culture Techniques / methods
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Clustered Regularly Interspaced Short Palindromic Repeats / genetics*
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Fetal Tissue Transplantation / methods
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Fetus / surgery
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Gene Editing / methods*
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Hematopoietic Stem Cell Transplantation / methods
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Hematopoietic Stem Cell Transplantation / veterinary
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Hematopoietic Stem Cells / metabolism*
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Humans
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Liver / surgery
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Lymphoma, T-Cell / genetics*
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Lymphoma, T-Cell / surgery
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Lymphoma, T-Cell / veterinary
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Mice
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Mice, Inbred C57BL
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Models, Animal
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Nuclear Proteins / metabolism
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Nucleophosmin
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Oncogene Proteins, Fusion / genetics*
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Receptor Protein-Tyrosine Kinases / metabolism
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Retroviridae Infections / complications
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Stem Cells / virology
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Young Adult
Substances
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NPM1 protein, human
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Npm1 protein, mouse
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Nuclear Proteins
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Oncogene Proteins, Fusion
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Nucleophosmin
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Alk protein, mouse
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Anaplastic Lymphoma Kinase
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Receptor Protein-Tyrosine Kinases