Does Rotavirus Vaccination Affect Longer-Term Intussusception Risk in US Infants?

Rachel M Burke; Jacqueline E Tate; Rebecca M Dahl; Negar Aliabadi; Umesh D Parashar

doi:10.1093/jpids/piz035

Does Rotavirus Vaccination Affect Longer-Term Intussusception Risk in US Infants?

J Pediatric Infect Dis Soc. 2020 Apr 30;9(2):257-260. doi: 10.1093/jpids/piz035.

Authors

Rachel M Burke^{1

2}, Jacqueline E Tate¹, Rebecca M Dahl³, Negar Aliabadi¹, Umesh D Parashar¹

Affiliations

¹ Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
² Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia.
³ Maximus Federal, contracting agency to the Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Abstract

Rotavirus vaccination has been associated with a short-term increased risk of intussusception. Our analysis of insurance claims for 1 858 827 US children with 544 recorded cases of intussusception found a nonsignificant decrease in intussusception (hazard ratio, 0.79 [95% confidence interval, 0.57-1.09]) in fully rotavirus-vaccinated children followed up to the age of 2 years.

Keywords: immunizations; intussusception; pediatric gastroenteritis; rotavirus; rotavirus vaccine.

Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2019.

MeSH terms

Follow-Up Studies
Humans
Infant
Intussusception / epidemiology
Intussusception / etiology*
Proportional Hazards Models
Risk
Rotavirus Infections / complications
Rotavirus Infections / prevention & control
Rotavirus Vaccines / adverse effects*
United States / epidemiology

Substances

Rotavirus Vaccines

Grants and funding

CC999999/ImCDC/Intramural CDC HHS/United States