RIFM fragrance ingredient safety assessment, 2-methylbutyric acid, CAS Registry Number 116-53-0

A M Api; F Belmonte; D Belsito; D Botelho; M Bruze; G A Burton Jr; J Buschmann; M L Dagli; M Date; W Dekant; C Deodhar; A D Fryer; S Gadhia; L Jones; K Joshi; S La Cava; A Lapczynski; M Lavelle; D C Liebler; M Na; D O'Brien; T M Penning; G Ritacco; J Romine; N Sadekar; D Salvito; T W Schultz; I G Sipes; G Sullivan; Y Thakkar; Y Tokura; S Tsang

doi:10.1016/j.fct.2019.110574

RIFM fragrance ingredient safety assessment, 2-methylbutyric acid, CAS Registry Number 116-53-0

Food Chem Toxicol. 2019 Aug:130 Suppl 1:110574. doi: 10.1016/j.fct.2019.110574. Epub 2019 Jun 11.

Authors

A M Api¹, F Belmonte¹, D Belsito², D Botelho¹, M Bruze³, G A Burton Jr⁴, J Buschmann⁵, M L Dagli⁶, M Date¹, W Dekant⁷, C Deodhar¹, A D Fryer⁸, S Gadhia¹, L Jones¹, K Joshi¹, S La Cava¹, A Lapczynski¹, M Lavelle¹, D C Liebler⁹, M Na¹, D O'Brien¹, T M Penning¹⁰, G Ritacco¹, J Romine¹, N Sadekar¹, D Salvito¹, T W Schultz¹¹, I G Sipes¹², G Sullivan¹³, Y Thakkar¹, Y Tokura¹⁴, S Tsang¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
² Member RIFM Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member RIFM Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE, 20502, Sweden.
⁴ Member RIFM Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁵ Member RIFM Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.
⁶ Member RIFM Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁷ Member RIFM Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
⁸ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
⁹ Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
¹⁰ Member of RIFM Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
¹¹ Member RIFM Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996- 4500, USA.
¹² Member RIFM Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: [email protected].
¹⁴ Member RIFM Expert Panel, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

PMID: 31199989
DOI: 10.1016/j.fct.2019.110574

No abstract available

Keywords: Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose, developmental, and reproductive toxicity; Skin sensitization.

Publication types

Review

MeSH terms

Animals
Butyrates / toxicity*
Consumer Product Safety
Endpoint Determination
Humans
No-Observed-Adverse-Effect Level
Odorants
Perfume / toxicity*
Risk Assessment
Salmonella typhimurium / drug effects

Substances

Butyrates
Perfume
2-methylbutanoic acid