Reactive nitrogen species in host-bacterial interactions

Curr Opin Immunol. 2019 Oct:60:96-102. doi: 10.1016/j.coi.2019.05.008. Epub 2019 Jun 12.

Abstract

Reactive nitrogen species play diverse and essential roles in host-pathogen interactions. Here, we review selected recent discoveries regarding nitric oxide (NO) in host defense and the pathogenesis of infection, mechanisms of bacterial NO resistance, production of NO by human macrophages, NO-based antimicrobial therapeutics and NO interactions with the gut microbiota.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Infections / drug therapy
  • Bacterial Infections / metabolism*
  • Bacterial Infections / microbiology*
  • Bacterial Physiological Phenomena*
  • Disease Resistance
  • Gastrointestinal Microbiome
  • Host-Pathogen Interactions*
  • Humans
  • Macrophages / immunology
  • Macrophages / metabolism
  • Macrophages / microbiology
  • Reactive Nitrogen Species / metabolism*

Substances

  • Reactive Nitrogen Species