Kidney Diseases Associated With Parvovirus B19, Hanta, Ebola, and Dengue Virus Infection: A Brief Review

Adv Chronic Kidney Dis. 2019 May;26(3):207-219. doi: 10.1053/j.ackd.2019.01.006.

Abstract

Viral infection-associated kidney diseases are an emerging public health issue in both developing and developed countries. Many new viruses have emerged with new paradigms of kidney injury, either directly through their cytopathic effect or indirectly through immune-mediated glomerulopathy, tubulointerstitial disease, and acute kidney injury as part of multiorgan failure. Herein, we will discuss Parvovirus, which causes glomerulopathy, and Hanta, Ebola, and Dengue viruses, which cause viral hemorrhagic fever and acute kidney injury. Clinical manifestations also depend on extrarenal organ systems involved. Diagnosis of these viral infections is mainly based on a high index of suspicion, serologic testing, and isolation of viral DNA/RNA. Management is largely conservative, as specific antiviral agents are unavailable.

Keywords: Acute kidney injury; Glomerular disease; Viral hemorrhagic fever; Virus-associated kidney disease.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / metabolism*
  • Acute Kidney Injury / physiopathology
  • Acute Kidney Injury / therapy
  • DNA, Viral / analysis
  • Dengue / diagnosis
  • Dengue / metabolism*
  • Dengue / physiopathology
  • Dengue / therapy
  • Erythema Infectiosum / diagnosis
  • Erythema Infectiosum / metabolism*
  • Erythema Infectiosum / physiopathology
  • Erythema Infectiosum / therapy
  • Glomerulonephritis / diagnosis
  • Glomerulonephritis / metabolism*
  • Glomerulonephritis / physiopathology
  • Glomerulonephritis / therapy
  • Hantavirus Infections / diagnosis
  • Hantavirus Infections / metabolism*
  • Hantavirus Infections / physiopathology
  • Hantavirus Infections / therapy
  • Hemorrhagic Fever, Ebola / diagnosis
  • Hemorrhagic Fever, Ebola / metabolism*
  • Hemorrhagic Fever, Ebola / physiopathology
  • Hemorrhagic Fever, Ebola / therapy
  • Humans
  • Nephritis / diagnosis
  • Nephritis / metabolism
  • Nephritis / physiopathology
  • Nephritis / therapy
  • Nephrotic Syndrome / diagnosis
  • Nephrotic Syndrome / metabolism*
  • Nephrotic Syndrome / physiopathology
  • Nephrotic Syndrome / therapy
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / metabolism
  • Parvoviridae Infections / physiopathology
  • Parvoviridae Infections / therapy
  • RNA, Viral / analysis
  • Serologic Tests

Substances

  • DNA, Viral
  • RNA, Viral