Objective: To explore the correlation of EB virus infection with the prognosis of B-ALL children.
Methods: The peripheral blood of children with newly diagnosed B-ALL admitted in Children's Hospital of Chongqing Medical University from January 2012 to December 2017 were collected, and the EBV DNA in plasma was detected by real-time quantitative PCR. The clinical data of B-ALL children were collected and the correlation of EBV infection with the prognosis of B-ALL children was analyzed.
Results: Among 162 B-ALL children, the EBV infection rate was 41.36%. Univariate analysis showed that the B-ALL children with EBV infection had the poor prognosis and higher risk of shorter survival time, as compared with B-ALL children without EBV infection (HR=2.373, 95% CI: 1.129-4.987) (P＜0.05), the multivariate analysis showed that the result was consistent with result of univariate analysis indicating that EBV infection was an independent predictor for poor prognosis of B-ALL children.
Conclusion: The EBV infection may play an important role in the occurrence and progression of B-ALL and is an independent predictor for poor prognosis, therefore the detection of EBV DNA in plasma of B-ALL children possesses an important significance for evaluation of B-ALL children's prognosis.
题目: EB病毒感染与急性B淋巴细胞白血病患儿的预后相关性研究.
目的: 探讨EB病毒感染与B-ALL患儿预后的关系.
方法: 收集2012年1月- 2017年12月在重庆医科大学附属儿童医院初诊为B-ALL的住院患儿外周血，运用实时荧光定量PCR的方法检测患儿血浆中EB病毒DNA。收集患儿病历资料，关联性分析EBV感染与B-ALL患儿预后的相关性.
结果: 162名B-ALL患儿中EB病毒感染率为41.36%。单因素分析结果显示，EB病毒感染的患儿预后差，生存期较短的风险高于未感染患儿（HR=2.373，95% CI:1.129-4.987），且差异有统计学意义（P=0.023）。多因素分析结果与单因素分析结果一致，这表明EB病毒感染是B-ALL患儿预后不良的独立预测因素.
结论: EB病毒感染可能在B-ALL的发生及进展中发挥了重要的作用，是B-ALL患儿预后不良的独立预测因素。因而，检测B-ALL患儿血浆中的EB病毒DNA对评估患儿疾病预后具有重要意义.