Guided bone regeneration (GBR) is an important technique to solve bone defect problems. In this technique, GBR barrier membranes play an irreplaceable role. GBR membranes can act as a barrier protecting fibroblasts from bone defects and promote osteoblast adhesion and proliferation, leading to bone regeneration. GBR barrier membranes should be enhanced because of the disadvantages of collagen membranes, which are extensively applied to the field of GBR. Therefore, various efforts have been devoted to modifying the antibacterial and osteogenic properties of GBR barrier membranes and developing novel materials. This article reviews the research advancements on the modification of GBR barrier membranes and discover future directions for the development of GBR barrier membranes to provide a reference for bone tissue engi-neering and repair.
引导骨再生术是解决骨组织缺损问题的重要技术，引导骨再生屏障膜在其中发挥着不可替代的作用。引导骨再生膜是防止成纤维细胞进入骨缺损部位的屏障，同时可促进成骨细胞的黏附、增殖和骨组织再生。由于目前广泛应用于引导骨再生的胶原膜尚存在一些缺陷，探索具有更优良性质的引导骨再生屏障膜成为一个重要的课题。因此出现了从抗菌性的改良、成骨性的改良和新材料的研发等多方面的努力以改良引导骨再生膜。本文回顾了近年来引导骨再生膜改进的研究成果和进展，展望了未来相关研究的发展方向，为进一步展开骨再生及修复的相关研究工作提供参考。.
Keywords: biological membrane; bone tissue engineering; collagen membrane; guided bone regeneration.