Evidence for linkage of Charcot-Marie-Tooth neuropathy (CMT1) to apolipoprotein A2 (Apo-A2)

V Ionasescu; R Anderson; T L Burns; C Searby; R Ionasescu; R Ferrell

Evidence for linkage of Charcot-Marie-Tooth neuropathy (CMT1) to apolipoprotein A2 (Apo-A2)

Am J Hum Genet. 1988 Jan;42(1):74-6.

Authors

V Ionasescu¹, R Anderson, T L Burns, C Searby, R Ionasescu, R Ferrell

Affiliation

¹ Department of Pediatrics, University of Iowa Hospitals, Iowa City 52242.

PMID: 3122561
PMCID: PMC1715300

Abstract

We studied 169 members of 15 families with Charcot-Marie-Tooth neuropathy (CMT1) showing male-to-male transmission and slow motor-nerve conduction velocities. Four of these families were informative for linkage to apolipoprotein A2 on chromosome 1 (1q21-23) with an overall lod score of 2.45 at theta = .001. There was no statistical evidence of genetic heterogeneity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apolipoprotein A-II
Apolipoproteins A / blood
Apolipoproteins A / genetics*
Charcot-Marie-Tooth Disease / blood
Charcot-Marie-Tooth Disease / genetics*
Chromosomes, Human, Pair 1
DNA / genetics
Female
Genetic Linkage*
Genetic Markers*
Humans
Lod Score
Male
Muscular Atrophy, Spinal / genetics*
Renin / genetics

Substances

Apolipoprotein A-II
Apolipoproteins A
Genetic Markers
DNA
Renin