MRI features of demyelinating disease associated with anti-MOG antibodies in adults

J Neuroradiol. 2019 Sep;46(5):312-318. doi: 10.1016/j.neurad.2019.06.001. Epub 2019 Jun 20.

Abstract

The spectrum of Myelin Oligodendrocytes Glycoprotein (MOG) antibody disease constitutes a recently described challenging entity, referring to a relatively new spectrum of autoimmune disorders with antibodies against MOG predominantly involving the optic nerve and spinal cord. The purpose of this article is to describe MRI features of MOG-AD involvement in the optic nerves, spinal cord and the brain of adults.

Keywords: AQP4-IgG; MOG-AD; MOG-IgG; MRI; NMOSD; Neuromyelitis Optica.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies
  • Brain / diagnostic imaging
  • Brain / pathology
  • Demyelinating Diseases / diagnostic imaging*
  • Demyelinating Diseases / immunology
  • Demyelinating Diseases / pathology*
  • Encephalitis / diagnostic imaging
  • Encephalitis / immunology
  • Encephalitis / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Myelin-Oligodendrocyte Glycoprotein / immunology
  • Myelitis / diagnostic imaging
  • Myelitis / immunology
  • Myelitis / pathology
  • Optic Nerve / diagnostic imaging
  • Optic Nerve / pathology
  • Optic Neuritis / diagnostic imaging
  • Optic Neuritis / immunology
  • Optic Neuritis / pathology
  • Spinal Cord / diagnostic imaging
  • Spinal Cord / pathology
  • Young Adult

Substances

  • Autoantibodies
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein