The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection

J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093. Epub 2019 Jun 24.

Abstract

Resident memory T cells (TRM) in the lung are vital for heterologous protection against influenza A virus (IAV). Environmental factors are necessary to establish lung TRM; however, the role of T cell-intrinsic factors like TCR signal strength have not been elucidated. In this study, we investigated the impact of TCR signal strength on the generation and maintenance of lung TRM after IAV infection. We inserted high- and low-affinity OT-I epitopes into IAV and infected mice after transfer of OT-I T cells. We uncovered a bias in TRM formation in the lung elicited by lower affinity TCR stimulation. TCR affinity did not impact the overall phenotype or long-term maintenance of lung TRM Overall, these findings demonstrate that TRM formation is negatively correlated with increased TCR signal strength. Lower affinity cells may have an advantage in forming TRM to ensure diversity in the Ag-specific repertoire in tissues.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Female
  • Immunologic Memory / immunology*
  • Influenza A virus / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections / immunology*
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology
  • T-Lymphocyte Subsets / immunology*

Substances

  • Receptors, Antigen, T-Cell