Development of a concise clinical index for predicting chronic chikungunya arthritis

Efrén Murillo-Zamora; Oliver Mendoza-Cano; Benjamín Trujillo-Hernández; José Guzmán-Esquivel; Agustín Lugo-Radillo; Martha Alicia Higareda-Almaraz; Juan José Evangelista-Salazar; Enrique Higareda-Almaraz; Verónica Benítes-Godínez

doi:10.1016/j.ijid.2019.06.020

Development of a concise clinical index for predicting chronic chikungunya arthritis

Int J Infect Dis. 2019 Sep:86:1-4. doi: 10.1016/j.ijid.2019.06.020. Epub 2019 Jun 22.

Authors

Efrén Murillo-Zamora¹, Oliver Mendoza-Cano², Benjamín Trujillo-Hernández³, José Guzmán-Esquivel⁴, Agustín Lugo-Radillo⁵, Martha Alicia Higareda-Almaraz⁶, Juan José Evangelista-Salazar⁷, Enrique Higareda-Almaraz⁸, Verónica Benítes-Godínez⁹

Affiliations

¹ Departamento de Epidemiología, Unidad de Medicina Familiar No. 19, Instituto Mexicano del Seguro Social, Av. Javier Mina 301, Col. Centro, C.P. 28000, Colima, Colima, México; Programa de Doctorado en Ciencias Médicas, Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, México. Electronic address: [email protected].
² Facultad de Ingeniería Civil, Universidad de Colima, km. 9 carretera Colima-Coquimatlán, Col. Jardines del Llano, C.P. 28400, Coquimatlán, Colima, México. Electronic address: [email protected].
³ Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, México. Electronic address: [email protected].
⁴ Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Col. Las Víboras, C.P. 28040, Colima, Colima, México; Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Av. de los Maestros No. 149, Col. Centro, C.P. 28000, Colima, Colima, México. Electronic address: [email protected].
⁵ CONACYT-Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca 68020, México. Electronic address: [email protected].
⁶ Instituto Mexicano del Seguro Social - Universidad de Guadalajara, Prisciliano Sánchez 530, Col. Centro, C.P. 44100, Guadalajara, Jalisco, México. Electronic address: [email protected].
⁷ Coordinación de Planeación y Enlace Institucional, Jefatura de Servicios de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Álvaro Obregón 184, Col. Centro, C.P. 28000, Colima, Colima, México. Electronic address: [email protected].
⁸ Investigador independiente, Manuel Payno 599, Col. Jardines de Vista Hermosa, C.P. 28017, Colima, Colima, México. Electronic address: [email protected].
⁹ Coordinación de Educación en Salud, Jefatura de Servicios de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Av. del Ejército 14, Col. Fray Junípero Serra, C.P. 63136 Tepic, Nayarit, México. Electronic address: [email protected].

PMID: 31238155
DOI: 10.1016/j.ijid.2019.06.020

Abstract

Objective: To evaluate the performance of an instrument for predicting chronic chikungunya arthritis (CCA) in adult patients.

Methods: A diagnostic test study was conducted and data from 217 confirmed cases of chikungunya virus (CHIKV) illness were analyzed. Two chronic chikungunya arthralgia scales (3-item CCAS-3 and 4-item CCAS-4) were constructed.

Results: Modest performance of the CCAS-3 scale was documented at the two given cut-off points. A CCAS-4 score ≥3 showed high sensitivity and specificity for predicting the persistence of CCA at 12 months after acute disease.

Conclusions: If replicated in other populations, these results could be useful in the medical management of patients with symptomatic CHIKV infection.

Keywords: Arthralgia; Chikungunya virus; Chronic pain; Predictive value of tests.

MeSH terms

Adult
Arthralgia / diagnosis
Arthralgia / virology
Arthritis / diagnosis*
Arthritis / virology
Chikungunya Fever / diagnosis*
Chikungunya Fever / virology
Chikungunya virus / physiology
Chronic Disease
Female
Humans
Male
Middle Aged