Activation of the TLR signaling pathway in CD8+ T cells counteracts liver endothelial cell-induced T cell tolerance

Cell Mol Immunol. 2019 Sep;16(9):774-776. doi: 10.1038/s41423-019-0255-8. Epub 2019 Jun 26.

Authors

Ejuan Zhang¹, Hu Yan¹, Qian Li², Ulf Dittmer², Huimin Yan¹, Mengji Lu³

Affiliations

¹ Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
² Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
³ Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany. [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Endothelium, Vascular / immunology*
Endothelium, Vascular / metabolism
Immune Tolerance / immunology*
Immunity, Cellular / immunology*
Liver / immunology*
Liver / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Signal Transduction
Toll-Like Receptor 2 / physiology*

Substances

Tlr2 protein, mouse
Toll-Like Receptor 2