Abstract
Drug addicts with persistent generalized lymphadenopathy displayed the following immunological abnormalities: an inverted OKT4/OKT8 ratio, a depressed in vitro blastogenetic response to phytohemagglutinin and pokeweed mitogen (PWM), a reduced ability of PMNL to phagocytose and kill Candida albicans spores and to migrate in presence of a chemotactic factor. Thymopentin treatment (50 mg s.c. 3 times/week for 3 weeks and repeated after 3 months at 50 mg s.c. once a week for 3 months) improved OKT4+ lymphocytes (p less than 0.05) and the blastogenesis to PWM (p less than 0.01); moreover, at the end of the first cycle, the chemotaxis of neutrophils was increased to normal values.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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AIDS-Related Complex / immunology
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AIDS-Related Complex / therapy*
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Adjuvants, Immunologic / pharmacology
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Adjuvants, Immunologic / therapeutic use*
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Adolescent
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Adult
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Chemotaxis / drug effects
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Drug Evaluation
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Female
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Humans
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Lymphocyte Activation / drug effects
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Lymphocytes / classification
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Male
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Peptide Fragments / pharmacology
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Peptide Fragments / therapeutic use*
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Phagocytosis / drug effects
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Substance-Related Disorders / complications
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Thymopentin
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Thymopoietins / pharmacology
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Thymopoietins / therapeutic use*
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Thymus Hormones / therapeutic use*
Substances
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Adjuvants, Immunologic
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Peptide Fragments
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Thymopoietins
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Thymus Hormones
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Thymopentin