Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia

J Emerg Med. 2019 Nov;57(5):720-722. doi: 10.1016/j.jemermed.2019.04.024. Epub 2019 Jun 24.

Abstract

Background: Metformin-associated lactic acidosis is a rare but serious complication of taking metformin. Making the diagnosis in the emergency department requires vigilance because the presentation can mimic other diseases.

Case report: We present a case of a patient with diabetes who presented moribund with symptoms and signs consistent with mesenteric ischemia. This diagnosis was seemingly confirmed through computed tomography, and as a result the patient was brought to surgery for emergent exploratory laparotomy. Our patient made a remarkable recovery upon initiation of hemodialysis, demonstrating the need to initiate this life-saving procedure early. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Metformin levels are rarely available in the setting of the emergency department. Clinicians must remain alert, recognize that imaging studies may be misleading, and consider hemodialysis early in addition to surgical interventions.

Keywords: lactic acidosis; mesenteric ischemia; metformin; metformin-associated lactic acidosis.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Lactic / blood
  • Acidosis, Lactic / etiology*
  • Creatinine / analysis
  • Creatinine / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Emergency Service, Hospital / organization & administration
  • Female
  • Humans
  • Hypoglycemic Agents / adverse effects
  • Hypoglycemic Agents / therapeutic use
  • Lactic Acid / analysis
  • Lactic Acid / blood
  • Laparotomy / methods
  • Mesenteric Ischemia / etiology*
  • Mesenteric Ischemia / surgery
  • Metformin / adverse effects*
  • Metformin / therapeutic use
  • Middle Aged

Substances

  • Hypoglycemic Agents
  • Lactic Acid
  • Metformin
  • Creatinine