Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis

Sex Transm Dis. 2019 Dec;46(12):805-809. doi: 10.1097/OLQ.0000000000001035.

Abstract

From February 2015 to October 2017, among 20 men who have sex with men with Mycoplasma genitalium-associated nongonococcal urethritis, 15% had macrolide resistance and S83I ParC mutations. Azithromycin followed by moxifloxacin cleared Mycoplasma genitalium in 2 of 2 with and 11 of 13 without S83I mutations. Dual failures were cleared after doxycycline. S83I mutations were not associated with moxifloxacin failure.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • DNA Topoisomerase IV / genetics*
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics
  • Homosexuality, Male*
  • Humans
  • Male
  • Mycoplasma Infections / drug therapy*
  • Mycoplasma genitalium / drug effects*
  • Mycoplasma genitalium / genetics
  • Sexual and Gender Minorities
  • Treatment Outcome
  • Urethritis / drug therapy*

Substances

  • Anti-Bacterial Agents
  • DNA Topoisomerase IV