Nanostructured lipid carriers loaded with free phytosterols for food applications

Valeria da Silva Santos; Bruno Brito Braz; Alan Ávila Silva; Lisandro Pavie Cardoso; Ana Paula Badan Ribeiro; Maria Helena Andrade Santana

doi:10.1016/j.foodchem.2019.125053

Nanostructured lipid carriers loaded with free phytosterols for food applications

Food Chem. 2019 Nov 15:298:125053. doi: 10.1016/j.foodchem.2019.125053. Epub 2019 Jun 21.

Authors

Valeria da Silva Santos¹, Bruno Brito Braz², Alan Ávila Silva³, Lisandro Pavie Cardoso⁴, Ana Paula Badan Ribeiro⁵, Maria Helena Andrade Santana⁶

Affiliations

¹ Department of Biotechnological Processes, School of Chemical Engineering, University of Campinas, 500 Albert Einstein Ave., Campinas, SP 13083-970, Brazil. Electronic address: [email protected].
² Department of Biotechnological Processes, School of Chemical Engineering, University of Campinas, 500 Albert Einstein Ave., Campinas, SP 13083-970, Brazil. Electronic address: [email protected].
³ Department of Food Technology, School of Food Engineering, University of Campinas, 80 Monteiro Lobato St., Campinas, SP 13083-970, Brazil. Electronic address: [email protected].
⁴ Department of Applied Physics, Institute of Physics Gleb Wataghin, University of Campinas, 777 Sérgio Buarque de Holanda St., 13083-859 Campinas, SP, Brazil. Electronic address: [email protected].
⁵ Department of Food Technology, School of Food Engineering, University of Campinas, 80 Monteiro Lobato St., Campinas, SP 13083-970, Brazil. Electronic address: [email protected].
⁶ Department of Biotechnological Processes, School of Chemical Engineering, University of Campinas, 500 Albert Einstein Ave., Campinas, SP 13083-970, Brazil. Electronic address: [email protected].

PMID: 31260972
DOI: 10.1016/j.foodchem.2019.125053

Abstract

The objective of this study was to develop nanostructured lipid carriers (NLCs) with free phytosterols (FP) using conventional fats and oils. Lipid matrices (LMs) and NLCs were produced with high oleic sunflower oil, fully hydrogenated canola (CA) and crambe (CR) oils by high-pressure homogenization (HPH). The NLCs were evaluated for hydrodynamic diameter (Z-ave), polydispersity index (PDI), and zeta potential (ZP). The melting behavior and polymorphism were investigated for both, the LMs and NLCs. The NLCs presented particle sizes ranging from 148.23 to 342.10 nm, PDI from 0.275 to 0.481, and ZP between -22.27 and -29.70 mV. The NLCs presented higher thermal resistance than that of the LMs. The use of CA and CR separately in the NLC formulations favored the incorporation of FP. The LMs and NLCs presented crystals in β-form and in mixtures of β' and β forms. The developed NLCs can be used for food enrichment, such as spreads, margarine, and beverages.

Keywords: Free phytosterols; Fully hydrogenated canola oil; Fully hydrogenated crambe oil; High oleic sunflower oil; Lipid nanoparticles; Thermal and crystalline behavior.

MeSH terms

Drug Carriers / chemistry
Lipids / chemistry*
Nanoparticles / chemistry*
Particle Size
Phytosterols / chemistry*
Rapeseed Oil / chemistry
Sunflower Oil / chemistry
Transition Temperature

Substances

Drug Carriers
Lipids
Phytosterols
Rapeseed Oil
Sunflower Oil