T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens

H R MacDonald; R Schneider; R K Lees; R C Howe; H Acha-Orbea; H Festenstein; R M Zinkernagel; H Hengartner

doi:10.1038/332040a0

T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens

Nature. 1988 Mar 3;332(6159):40-5. doi: 10.1038/332040a0.

Authors

H R MacDonald¹, R Schneider, R K Lees, R C Howe, H Acha-Orbea, H Festenstein, R M Zinkernagel, H Hengartner

Affiliation

¹ Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

PMID: 3126397
DOI: 10.1038/332040a0

Abstract

T lymphocytes reactive with the product of the Mlsa-allele of the minor lymphocyte stimulating (Mls) locus use a predominant T-cell receptor beta-chain variable gene segment (V beta 6). Such V beta 6-bearing T cells are selectively eliminated in the thymus of Mlsa-bearing mice, consistent with a model in which tolerance to self antigens is achieved by clonal deletion.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigens, Surface / genetics
Antigens, Surface / immunology*
Immune Tolerance*
Major Histocompatibility Complex
Mice
Mice, Inbred Strains
Minor Lymphocyte Stimulatory Antigens
Receptors, Antigen, T-Cell / genetics*
Receptors, Antigen, T-Cell / immunology
T-Lymphocytes / immunology*
Thymus Gland / immunology

Substances

Antigens, Surface
Minor Lymphocyte Stimulatory Antigens
Receptors, Antigen, T-Cell