Objective: To evaluate the role of combining relative alpha variability and electroencephalogram (EEG) reactivity to predict the prognosis of hypoxic-ischemic encephalopathy(HIE) in adult patients. Methods: A total of 28 adult patients with HIE admitted to general intensive care unit at Xiangya Hospital in Central South University were enrolled in this observational study from January2016 to April 2017. These patients with body temperature over 35℃ after 72-hour admission could be continuously monitored at least 12 hours byEEG.At the same time,each patient was assessed for EEG reactivity.Then we analyzed the correlation between EEG reactivity, relative alpha variability and clinical prognosis. Results: EEG reactivity was elicited in 15/28 patients, among whom 12 patients had a good outcome. While in the other 13 patients, EEG reactivity was not elicited, among whom only 3 patients had a good outcome. As to the results ofrelative alpha variability,11/13 patients with degree 3-4were of good prognosis; while only 3/15 patients with degree 1-2 were of good prognosis. Glasgow coma scale(GCS), EEG reactivity, and relative alpha variability were correlated with clinical outcome(χ(2)=5.073,9.073,-3.626, respectively,all P<0.05). The sensitivity of GCS, EEG reactivity, and relative alpha variability to predict the poor prognosis were 69.2%, 76.9%, 84.6%, respectively. The specificity were 73.3%, 80.0%, 73.3%, respectively. The consistency rates were 71.4%, 78.6%, 78.6%, respectively. The positive predictive values were 69.2%, 76.9%, 73.3%, respectively. The negative predictive values were 73.3%, 80.0%, 84.6%, respectively. More importantly, the accuracy of the relative alpha variability combined with EEG reactivity for the prediction of poor prognosis was much higher with the positive predictive value of 90.0%,the specificity of 93.3%, the sensitivity of 69.2%, the consistency rate of 82.1%,and the negative predictive values of 77.8%. Conclusions: The combination of relative alpha variability and EEG reactivityis reliable to predict clinical outcome of patients with HIE.
目的： 探讨相对α变异性联合脑电反应性对成人缺血缺氧性脑病（HIE）患者临床预后的评估价值。 方法： 选2016年1月至2017年4月中南大学湘雅医院重症医学科收治的28例成人HIE致昏迷患者，入院72 h内体温超过35 ℃行定量脑电图监测并持续至少12 h，同时行脑电反应性检查，分析脑电反应性、相对α变异性与患者预后的关系。 结果： 28例患者中脑电有反应性者15例，12例预后良好；无反应性者13例，3例预后良好。相对α变异性3~4级者13例，11例预后良好；相对α变异性1~2级者15例，4例预后良好。格拉斯哥评分、脑电反应性、相对α变异性与患者预后有关联（χ(2)值分别为5.073、9.073、-3.626，P<0.05）。格拉斯哥评分3~5分、脑电无反应性、相对α变异性1~2级对HIE患者预后不良判断的敏感性分别为69.2%、76.9%、84.6%；特异性分别为73.3%、80.0%、73.3%；符合率分别为71.4%、78.6%、78.6%；阳性预测值分别为69.2%、76.9%、73.3%；阴性预测值分别为73.3%、80.0%、84.6%。联合相对α变异性1~2级和脑电无反应性对成人HIE患者预后不良的预测准确率更高，阳性预测值90.0%，特异性93.3%，敏感性69.2%，符合率82.1%，阴性预测值77.8%。 结论： 相对α变异性联合脑电反应性可反映脑损伤程度，两者联合能可靠评估成人HIE患者的预后。.
Keywords: Electroencephalogram reactivity; Hypoxia-ischemia brain encephalopathy; Prognosis; Relative alpha variability.