Factors associated with genetic testing in a cohort of breast cancer survivors

Breast J. 2019 Nov;25(6):1241-1244. doi: 10.1111/tbj.13440. Epub 2019 Jul 3.

Abstract

We examined factors associated with self-reported use of genetic testing among breast cancer survivors based on a 2015 cross-sectional survey at eight Midwestern sites. Genetic testing was reported in 39% of our 1235 study participants, with higher utilization among those aged <50 and with a triple-negative cancer. Bilateral mastectomy, having relatives with breast cancer, and younger age were associated with increased genetic testing use. Increasing income, in interaction with age, was associated with use of genetic testing among younger but not older patients. Rural residency emerged as a possible barrier for genetic testing among women with triple-negative cancer.

Keywords: breast cancer; cancer genetic testing; pathogenic germline variant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / therapy
  • Cancer Survivors* / psychology
  • Cancer Survivors* / statistics & numerical data
  • Causality
  • Cross-Sectional Studies
  • Female
  • Genetic Testing / statistics & numerical data*
  • Health Services Accessibility
  • Humans
  • Middle Aged
  • Procedures and Techniques Utilization / statistics & numerical data*
  • Socioeconomic Factors
  • Triple Negative Breast Neoplasms / genetics
  • Triple Negative Breast Neoplasms / therapy
  • United States