Putting Stem Cells on a Low-Fat Diet Switches Their Pluripotent State

Cell Stem Cell. 2019 Jul 3;25(1):3-5. doi: 10.1016/j.stem.2019.06.002.

Abstract

Previous work demonstrating the importance of stem cell metabolism in regulating development ignited a debate on how intrinsic versus extrinsic conditions influence metabolic programming of epigenetics. In this issue of Cell Stem Cell, Cornacchia et al. show that exogenous lipids regulate an acetyl-CoA-dependent switch to influence the intrinsic pluripotent state of hPSCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Differentiation
  • Diet, Fat-Restricted
  • Embryonic Stem Cells*
  • Humans
  • Lipids
  • Pluripotent Stem Cells*

Substances

  • Lipids