Evaluation of Rapid Diagnostic Tests for Assessment of Hepatitis B in Resource-Limited Settings

Ann Glob Health. 2019 Jul 4;85(1):98. doi: 10.5334/aogh.2562.

Abstract

Chronic Hepatitis B (HBV) is the most important cause of liver disease worldwide. There is a need for low-cost tests to aid in diagnosis and management of HBV infection in resource-limited settings. We evaluated the utility of several rapid diagnostic tests (RDT) in three different continents (Europe, South America, Africa). The HBsAg RDT showed optimal sensitivity and specificity. The anti-HBeAb RDT showed acceptable sensitivity and excellent specificity. Our results suggest that these RDTs could be used for screening and management of HBV.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Argentina
  • Diagnostic Techniques, Digestive System
  • Ethiopia
  • Female
  • Hepatitis B Antibodies / blood*
  • Hepatitis B Surface Antigens / blood*
  • Hepatitis B Surface Antigens / immunology
  • Hepatitis B e Antigens / blood*
  • Hepatitis B e Antigens / immunology
  • Hepatitis B, Chronic / blood*
  • Hepatitis B, Chronic / diagnosis*
  • Humans
  • Male
  • Netherlands
  • ROC Curve
  • Time Factors

Substances

  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens