Early changes in diaphragmatic function evaluated using ultrasound in cardiac surgery patients: a cohort study

J Clin Monit Comput. 2020 Jun;34(3):559-566. doi: 10.1007/s10877-019-00350-8. Epub 2019 Jul 5.

Abstract

Little is known about the evolution of diaphragmatic function in the early post-cardiac surgery period. The main purpose of this work is to describe its evolution using ultrasound measurements of muscular excursion and thickening fraction (TF). Single-center prospective study of 79 consecutive uncomplicated elective cardiac surgery patients, using motion-mode during quiet unassisted breathing. Excursion and TF were measured sequentially for each patient [pre-operative (D1), 1 day (D2) and 5 days (D3) after surgery]. Pre-operative median for right and left hemidiaphragmatic excursions were 1.8 (IQR 1.6 to 2.1) cm and 1.7 (1.4 to 2.0) cm, respectively. Pre-operative median right and left thickening fractions were 28 (19 to 36) % and 33 (22 to 51) %, respectively. At D2, there was a reduction in both excursion (right: 1.5 (1.1 to 1.8) cm, p < 0.001, left: 1.5 (1.1 to 1.8), p = 0.003) and thickening fractions (right: 20 (15 to 34) %, p = 0.021, left: 24 (17 to 39) %, p = 0.002), followed by a return to pre-operative values at D3. A positive moderate correlation was found between excursion and thickening fraction (Spearman's rho 0.518 for right and 0.548 for left hemidiaphragm, p < 0.001). Interobserver reliability yielded a bias below 0.1 cm with limits of agreement (LOA) of ± 0.3 cm for excursion and - 2% with LOA of ± 21% for thickening fractions. After cardiac surgery, the evolution of diaphragmatic function is characterized by a transient impairment followed by a quick recovery. Although ultrasound diaphragmatic excursion and thickening fraction are correlated, excursion seems to be a more feasible and reproducible method in this population.

Keywords: Cardiac surgery; Diaphragm; Excursion, thickening; Ultrasound.

MeSH terms

  • Aged
  • Cardiac Surgical Procedures
  • Cohort Studies
  • Diaphragm / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Monitoring, Physiologic / methods*
  • Motion
  • Preoperative Period
  • Prospective Studies
  • Reproducibility of Results
  • Respiration*
  • Tertiary Care Centers
  • Time Factors
  • Ultrasonography*
  • User-Computer Interface