Background/aim: Several studies have investigated prognostic factors in patients with T2 gastric cancer, but no consensus has been reached to date. The aim was to investigate the clinicopathological significance of the status of tumor invasion into the muscularis propria (MP) in T2 gastric cancer patients.
Patients and methods: A total of 113 patients with T2 cancer were enrolled. The status of caner invasion was analyzed according to width (extent of horizontal invasion) and depth (extent of vertical invasion).
Results: The prognosis of the group with wide width of invasion (≥1.5 cm) was significantly poorer than that of the group with narrow width of invasion (<1.5 cm) (p=0.001). Multivariate analysis identified the width, and not the depth, as an independent prognostic factor. The analysis according to AJCC N stage showed that the width, and not the nodal status, was an independent prognostic factor in the N2-N3 patients (p=0.005).
Conclusion: Measurement of the width of tumor invasion into the MP was useful to understand the malignant potential of T2 gastric cancer.
Keywords: Gastric cancer; muscularis propria; prognosis; tumor invasion.
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.