Abstract
The immunochromatographic assay NG-Test Carba 5 (NG-Biotech) was evaluated with a collection of 107 carbapenemase-producing nonfermenters (CP-NF) (55 Pseudomonas spp., 51 Acinetobacter spp., and 1 Achromobacter xylosoxidans isolate) and 61 carbapenemase-negative isolates. All KPC, VIM, and NDM carbapenemase producers tested were accurately detected. Of the 16 IMP variants tested, 6 (37.5%) variants were not detected. Considering the epidemiology of CP-NFs in France, the NG-Test Carba 5 would detect 89.4% of CP Pseudomonas spp. but only 12.9% of CP Acinetobacter spp.
Keywords:
Acinetobacter; IMP; KPC; NDM; Pseudomonas aeruginosa; VIM; carbapenemases; rapid diagnostic.
Copyright © 2019 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Achromobacter denitrificans / drug effects
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Achromobacter denitrificans / enzymology
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Achromobacter denitrificans / genetics*
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Achromobacter denitrificans / isolation & purification
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Acinetobacter / drug effects
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Acinetobacter / enzymology
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Acinetobacter / genetics*
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Acinetobacter / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Carbapenems / pharmacology
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Chromatography, Affinity / methods*
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Chromatography, Affinity / standards
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France / epidemiology
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Gene Expression
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Gram-Negative Bacterial Infections / drug therapy
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Gram-Negative Bacterial Infections / epidemiology
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Microbial Sensitivity Tests / standards
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Pseudomonas / drug effects
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Pseudomonas / enzymology
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Pseudomonas / genetics*
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Pseudomonas / isolation & purification
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Sensitivity and Specificity
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Species Specificity
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-Lactamases
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carbapenemase