A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Affiliations

• ¹ Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.
• ² Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada.
• ³ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
• ⁴ Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
• ⁵ Princess Margaret Cancer Center-OICR Translational Genomics Laboratory, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
• ⁶ Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
• ⁷ Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G0A4, Canada.
• ⁸ Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, Department of Pediatrics, University of Melbourne, Melbourne, VIC 3052, Australia.
• ⁹ Department of Hematology-Oncology, Seattle Children's Hospital, Seattle, WA 98105, USA.
• ¹⁰ Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
• ¹¹ Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid 28009, Spain.
• ¹² Department of Pediatric Oncology, Hospital Infantil Virgen del Rocio, Seville 41013, Spain.
• ¹³ Department of Pathology, Neuropathology Division, Hospital Universitario Virgen del Rocio, Seville 41013, Spain.
• ¹⁴ University of Alabama at Birmingham, Birmingham, AL 35294, USA.
• ¹⁵ Department of Neurosurgery, University of Alabama at Birmingham, Birmingham AL 35294, USA.
• ¹⁶ Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.
• ¹⁷ Department of Pediatrics, Virginia Commonwealth University, Richmond, VA 23298-0631, USA.
• ¹⁸ Department of Neurosurgery, Kurume University, Fukuoka 830-0011, Japan.
• ¹⁹ Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Medical University, Taipei 11031, Taiwan.
• ²⁰ Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea.
• ²¹ Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul 03080, Korea.
• ²² Department of Neurosurgery, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
• ²³ Children's Brain Tumor Research Centre, Queen's Medical Centre University of Nottingham, Nottingham NG72UH, UK.
• ²⁴ Department of Pediatric Hematology and Oncology at Children's Healthcare of Atlanta and the Emory University School of Medicine, Atlanta, GA 30322, USA.
• ²⁵ Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, ON K1H8L1, Canada.
• ²⁶ Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada.
• ²⁷ Department of Pediatric Oncology, Alberta Children's Hospital, Calgary, AB T3B6A8, Canada.
• ²⁸ Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC 20010, USA.
• ²⁹ Department of Neuropathology Huashan Hospital, Fudan University, Shanghai 200040, China.
• ³⁰ The Tumor Bank, Children's Cancer Research Unit, Kids Research, the Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
• ³¹ Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1H8M5, Canada.
• ³² Department of Pathology, CHU Sainte-Justine Research Center, Université de Montréal, Montréal, QC H3T1C5, Canada.
• ³³ Paediatric Haematology and Oncology, Southampton Children's Hospital, Southampton SO166YD, UK.
• ³⁴ Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.
• ³⁵ Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Department of Pathology, The Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
• ³⁶ Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada.
• ³⁷ Departments of Pediatrics and Human Genetics, McGill University, Montréal, QC H3A0C7, Canada.
• ³⁸ McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON L8S4K1, Canada.
• ³⁹ Structural Genomics Consortium, University of Toronto, Toronto, ON M5G1L7, Canada.
• ⁴⁰ Department of Pediatrics, Division of Hematology and Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
• ⁴¹ Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, CA 92093, USA.
• ⁴² Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address: [email protected].