Development and Cell Biology of the Blood-Brain Barrier

Annu Rev Cell Dev Biol. 2019 Oct 6:35:591-613. doi: 10.1146/annurev-cellbio-100617-062608. Epub 2019 Jul 12.

Abstract

The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue. A unique feature of the central nervous system (CNS) vasculature is the blood-brain barrier (BBB). The BBB regulates substance influx and efflux to maintain a homeostatic environment for proper brain function. Here, we review the development and cell biology of the BBB, focusing on the cellular and molecular regulation of barrier formation and the maintenance of the BBB through adulthood. We summarize unique features of CNS endothelial cells and highlight recent progress in and general principles of barrier regulation. Finally, we illustrate why a mechanistic understanding of the development and maintenance of the BBB could provide novel therapeutic opportunities for CNS drug delivery.

Keywords: astrocytes; blood-brain barrier; central nervous system; endothelial cells; neurovascular unit; pericytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Basement Membrane / cytology
  • Basement Membrane / metabolism
  • Biological Transport / genetics
  • Biological Transport / physiology*
  • Blood-Brain Barrier / cytology*
  • Blood-Brain Barrier / growth & development*
  • Blood-Brain Barrier / metabolism
  • Brain / cytology
  • Brain / physiology
  • Central Nervous System / cytology*
  • Central Nervous System / metabolism
  • Endothelial Cells / cytology*
  • Endothelial Cells / metabolism
  • Endothelial Cells / physiology
  • Homeostasis
  • Humans
  • Leukocytes
  • Neurovascular Coupling / physiology
  • Pericytes / cytology
  • Tight Junctions
  • Transcytosis / physiology
  • Wnt Signaling Pathway / genetics
  • Wnt Signaling Pathway / physiology