Abstract
Clinical Enterobacteriacae isolates with a colistin minimum inhibitory concentration (MIC) ≥4 mg/L from a United States hospital were screened for the mcr-1 gene using real-time polymerase chain reaction (RT-PCR) and confirmed by whole-genome sequencing. Four colistin-resistant Escherichia coli isolates contained mcr-1. Two isolates belonged to the same sequence type (ST-632). All subjects had prior international travel and antimicrobial exposure.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aged
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Colistin / pharmacology*
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Drug Resistance, Bacterial / genetics*
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Escherichia coli / genetics*
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Escherichia coli Infections / genetics*
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics*
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Female
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Humans
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Male
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Michigan
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Microbial Sensitivity Tests
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Whole Genome Sequencing
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Young Adult
Substances
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Colistin