New antibiotics 4181-A and B from Streptomyces griseus; taxonomy, fermentation, isolation and characterization

T Otani; I Yamawaki; H Matsumoto; Y Minami; Y Yamada; T Marunaka; C Q Qi; T Tian; R Zhang; M Y Xie

doi:10.7164/antibiotics.41.275

New antibiotics 4181-A and B from Streptomyces griseus; taxonomy, fermentation, isolation and characterization

J Antibiot (Tokyo). 1988 Mar;41(3):275-81. doi: 10.7164/antibiotics.41.275.

Authors

T Otani¹, I Yamawaki, H Matsumoto, Y Minami, Y Yamada, T Marunaka, C Q Qi, T Tian, R Zhang, M Y Xie, et al.

Affiliation

¹ Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.

PMID: 3130363
DOI: 10.7164/antibiotics.41.275

Abstract

The new antibiotics 4181-A and B were isolated from the fermentation broth of Streptomyces griseus, a soil isolate. Their molecular formulae were determined as C29H21NO9 and C28H19NO9, respectively. The UV, IR and NMR spectra suggest that they possess a quinone moiety in their structures. They were found to have antibacterial, antifungal and antitumor activity.

MeSH terms

Animals
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Chemical Phenomena
Chemistry
Fermentation
Leukemia P388 / drug therapy
Mice
Microbial Sensitivity Tests
Quinones / isolation & purification
Streptomyces griseus / classification*
Streptomyces griseus / metabolism

Substances

Anti-Bacterial Agents
Quinones
antibiotic 4181-B
antibiotic 4181-A