[Economic evaluation of pneumococcal vaccination in adults aged over 65 years in Castilla y León (SPAIN)]

Rev Esp Geriatr Gerontol. 2019 Nov-Dec;54(6):309-314. doi: 10.1016/j.regg.2019.05.004. Epub 2019 Jul 12.
[Article in Spanish]

Abstract

Introduction: The burden of disease due to pneumonia in older adults has a major impact on health systems. The aim of this study is to carry out an economic evaluation of the vaccination strategy against Streptococcus pneumoniae using the 13-valent pneumococcal conjugate vaccine.

Material and methods: A simulated economic model has been developed in the form of a decision tree to evaluate the cost of the vaccination strategy in the population over 65 years of the Valladolid-East Health Area, versus non-vaccination, using a Monte Carlo probabilistic analysis.

Results: Streptococcus pneumoniae annually generates 557.24 cases of pneumococcal disease in the Valladolid-East Health Area, and 506.60 episodes have pneumonia symptoms. Vaccination of the cohort over 65 years of age is an efficient measure from the third year, with a cost per quality-adjusted life years (QALY) of 20,496.20 €. The number of QALYs gained in a decade is 86.07 and an amount of 216.252.89 € with this vaccination strategy would be saved.

Conclusions: The evaluation of the different incremental costs (QALY,euros) in the years of follow-up, the pneumococcus vaccination program in people over 65 in Castilla y León is cost-effective.

Keywords: Cost-effectiveness; Coste/efectividad; Streptococcus pneumoniae; Vaccination; Vacunación.

MeSH terms

  • Aged
  • Community-Acquired Infections / economics
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / prevention & control
  • Cost Savings / economics
  • Decision Trees
  • Hospitalization / statistics & numerical data
  • Humans
  • Incidence
  • Models, Economic
  • Pneumococcal Vaccines / administration & dosage
  • Pneumococcal Vaccines / economics*
  • Pneumonia, Pneumococcal / economics
  • Pneumonia, Pneumococcal / epidemiology
  • Pneumonia, Pneumococcal / prevention & control*
  • Quality-Adjusted Life Years*
  • Spain
  • Streptococcus pneumoniae / immunology*
  • Vaccination / economics*
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / economics

Substances

  • Pneumococcal Vaccines
  • Vaccines, Conjugate