It is identified that long non-coding RNAs (lncRNAs) play important roles in cancer progression and metastasis. LncRNA SNHG7 was reported to play an oncogenic role in the progression of cancers including prostate cancer. However, its potential regulatory mechanism of endothelial-mesenchymal transition in PCa remains unclear. In this study, We found a lncRNA SNHG7 was overexpressed in PCa cell lines and tissues. LncRNA SNHG7 promotes prostate cancer migration and invasion by modulating EMT. Further study indicated that lncRNA SNHG7 acts as a sponge for miRNA-324-3p and positively regulates WNT2B by a sponge effect. Moreover, We confirmed that WNT2B, an important protein in the Wnt signal pathway, promotes the malignant phenotype of PCa cells and mediated the biological effects exerted by lncRNA SNHG7. Overall, our study suggested that lncRNA SNHG7 could promote PCa EMT via miR-324-3p and WNT2B in vitro. The lncRNA SNHG7/miR-324-3p /WNT2B axis regulatory network might provide a potential new therapeutic strategy for PCa treatment.
Keywords: Epithelial-mesenchymal transition; LncRNA; Prostate cancer; SNHG7; WNT2B.
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