Fatal hemolytic disease of the fetus and newborn caused by anti-Jra antibody: A case report and literature review

Transfus Apher Sci. 2020 Feb;59(1):102605. doi: 10.1016/j.transci.2019.06.029. Epub 2019 Jul 10.

Abstract

The Jra antigen of the JR blood group system is a highly prevalent red blood cell antigen. Although anti-Jra-associated hemolytic disease of the fetus and newborn (HDFN) is generally considered mild-to-moderate, a rare fatal case was recently reported. We report the third example of HDFN-related anti-Jra with fatal outcomes. The clinical significance of anti-Jra antibody as a cause of HDFN should be reassessed.

Keywords: ABCG2; Anti-Jr(a); Fatality; Hemolytic disease of the fetus and newborn.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Blood Group Antigens / immunology*
  • Erythroblastosis, Fetal / diagnosis*
  • Female
  • Humans
  • Infant, Newborn
  • Isoantibodies / immunology*
  • Pregnancy

Substances

  • Blood Group Antigens
  • Isoantibodies