HIV-2 antisera cross-neutralize HIV-1

AIDS. 1988 Apr;2(2):95-100. doi: 10.1097/00002030-198804000-00004.

Abstract

The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / physiology*
  • Antibody Specificity
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • HIV / immunology*
  • HIV Antibodies
  • Humans
  • Immune Sera / pharmacology*
  • Neutralization Tests* / methods
  • Precipitin Tests

Substances

  • Antibodies, Viral
  • HIV Antibodies
  • Immune Sera