Pathological fracture of non-ossifying fibroma associated with neurofibromatosis type 1

BMJ Case Rep. 2019 Jul 21;12(7):e228170. doi: 10.1136/bcr-2018-228170.

Abstract

We report the management of a pathological fracture through a proximal tibial non-ossifying fibroma (NOF) in a 13-year-old girl with neurofibromatosis type 1 (NF1). The fracture was minimally displaced, and the lesion had clinical features of a NOF, and therefore biopsy was not required. Operative fixation has been the preferred method of treatment for pathological fractures through NOF associated with NF1. Multiple NOFs associated with NF1 are rare but can coalesce resulting in large lesions with an increased risk of pathological fracture. In cases which permit, non-operative treatment with cast immobilisation can yield satisfactory results.

Keywords: accidents; injuries; knee injuries; orthopaedics.

Publication types

  • Case Reports

MeSH terms

  • Accidental Falls
  • Adolescent
  • Bone Neoplasms / complications
  • Bone Neoplasms / diagnostic imaging*
  • Casts, Surgical*
  • Conservative Treatment
  • Female
  • Fracture Healing
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / therapy*
  • Humans
  • Neurofibromatosis 1 / complications
  • Neurofibromatosis 1 / diagnostic imaging*
  • Tibia / injuries*