Paraneoplastic Cushing's syndrome and hypercalcemia arising from metastatic endometrioid endometrial adenocarcinoma: A case report

Evelyn Mitchell; Marcia Ciccone; Bing Zhang; Arnold Tsai; Laurie L Brunette

doi:10.1016/j.gore.2019.06.005

Paraneoplastic Cushing's syndrome and hypercalcemia arising from metastatic endometrioid endometrial adenocarcinoma: A case report

Gynecol Oncol Rep. 2019 Jun 18:29:58-60. doi: 10.1016/j.gore.2019.06.005. eCollection 2019 Aug.

Authors

Evelyn Mitchell¹, Marcia Ciccone¹, Bing Zhang², Arnold Tsai², Laurie L Brunette¹

Affiliations

¹ Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, USA.
² Department of Medicine, Keck School of Medicine, University of Southern California, USA.

Abstract

•Paraneoplastic Cushing's syndrome is rarely seen in gynecologic cancers, appearing only in case reports•It almost universally results in acute decompensation and portends a poor prognosis•We describe a patient with metastatic endometrial carcinoma with both paraneoplastic Cushing's syndrome and hypercalcemia•High clinical suspicion for malignancy is essential, as these syndromes improve with treatment of the underlying malignancy.

Keywords: ACTH, adrenocorticotrophic hormone; Cushing's syndrome; Endometrial cancer; Hypercalcemia; PNES, paraneoplastic endocrine syndromes; PNS, paraneoplastic syndromes; Paraneoplastic syndrome.

Publication types

Case Reports