Abstract
Sixteen patients were included in the analysis of this double-blind crossover study comparing the effect of sodium cromoglycate, reproterol, sodium cromoglycate plus reproterol, and placebo in exercise-induced asthma. Both the sodium cromoglycate and the reproterol-containing treatment significantly inhibited exercise-induced asthma. The best protection is effected by the combination of sodium cromoglycate and reproterol. A synergistic effect of both medications could not be confirmed statistically so that their combined effect is simply additive.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Administration, Inhalation
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Adolescent
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Adult
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Asthma / drug therapy*
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Asthma, Exercise-Induced / drug therapy*
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Bronchodilator Agents / therapeutic use*
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Child
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Clinical Trials as Topic
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Cromolyn Sodium / administration & dosage
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Cromolyn Sodium / therapeutic use*
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Double-Blind Method
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Drug Combinations
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Drug Therapy, Combination
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Humans
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Metaproterenol / administration & dosage
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Metaproterenol / analogs & derivatives*
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Metaproterenol / therapeutic use
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Placebos
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Random Allocation
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Theophylline / administration & dosage
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Theophylline / analogs & derivatives*
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Theophylline / therapeutic use
Substances
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Bronchodilator Agents
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Drug Combinations
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Placebos
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reproterol
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Metaproterenol
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Theophylline
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Cromolyn Sodium