Molecular epidemiology and intercontinental spread of cholera

Ankur Mutreja; Gordon Dougan

doi:10.1016/j.vaccine.2019.07.038

Molecular epidemiology and intercontinental spread of cholera

Vaccine. 2020 Feb 29:38 Suppl 1:A46-A51. doi: 10.1016/j.vaccine.2019.07.038. Epub 2019 Jul 22.

Authors

Ankur Mutreja¹, Gordon Dougan²

Affiliations

¹ Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Translational Health Science and Technology Institute, Faridabad, Haryana 121001, India; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1S, United Kingdom. Electronic address: [email protected].
² Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1S, United Kingdom.

PMID: 31345641
DOI: 10.1016/j.vaccine.2019.07.038

Abstract

Whole genome sequence analysis has revealed the phylogenetic structure of Vibrio cholerae and has shown that the current seventh pandemic is highly clonal, emerging from a single source. Such analysis has the potential to become a powerful public health tool as we build public sequence databases, and as the speed of sequencing and analysis increases. Examples of such studies, as applied to different settings of the disease cholera, are described and discussed.

Keywords: Cholera; Epidemic; Epidemiology; Genomics; Outbreak; Pandemic; Spread; Transmission; Vaccine; Vibrio.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cholera* / epidemiology
Genome, Bacterial
Global Health
Humans
Molecular Epidemiology*
Pandemics
Phylogeny*
Vibrio cholerae / classification*