Abstract
Low-grade gliomas (LGG) are among the most common types of brain tumors in children and young adults. These tumors often consist of solid and cystic components. Bevacizumab is a documented treatment for progressive LGG, yet the impact of therapy on the cystic component of these tumors is unknown. We present four patients with prominently cystic LGG treated with bevacizumab at the time of progression. In each case, the cystic component responded to treatment. This is the first known study to investigate bevacizumab's impact on the cystic component of low-grade gliomas.
Keywords:
astrocytoma; bevacizumab; cyst; ganglioglioma; low-grade glioma; pediatric.
© 2019 Wiley Periodicals, Inc.
MeSH terms
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Adolescent
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Adult
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Angiogenesis Inhibitors / therapeutic use*
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Astrocytoma / blood supply
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Astrocytoma / diagnostic imaging
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Astrocytoma / radiotherapy
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Astrocytoma / surgery
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Bevacizumab / therapeutic use*
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Brain Edema / drug therapy
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / therapy
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Brain Stem Neoplasms / blood supply
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Brain Stem Neoplasms / diagnostic imaging
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Brain Stem Neoplasms / drug therapy
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Central Nervous System Cysts / diagnostic imaging
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Central Nervous System Cysts / drug therapy*
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Central Nervous System Cysts / physiopathology
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Child
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Child, Preschool
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Combined Modality Therapy
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Cranial Irradiation
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Cytoreduction Surgical Procedures
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Female
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Ganglioglioma / complications
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Ganglioglioma / diagnostic imaging
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Ganglioglioma / drug therapy
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Ganglioglioma / surgery
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Glioma / diagnostic imaging
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Glioma / drug therapy*
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Glioma / therapy
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Humans
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Male
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Spinal Cord Compression / drug therapy
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Spinal Cord Compression / etiology
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Spinal Neoplasms / complications
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Spinal Neoplasms / diagnostic imaging
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Spinal Neoplasms / drug therapy*
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Spinal Neoplasms / surgery
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Thoracic Vertebrae* / diagnostic imaging
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Thoracic Vertebrae* / surgery
Substances
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Angiogenesis Inhibitors
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Bevacizumab