Phenothiazine-induced systemic lupus erythematosus with superior vena cava syndrome: case report and review of the literature

V D Steen; R Ramsey-Goldman

doi:10.1002/art.1780310716

Phenothiazine-induced systemic lupus erythematosus with superior vena cava syndrome: case report and review of the literature

Arthritis Rheum. 1988 Jul;31(7):923-6. doi: 10.1002/art.1780310716.

Authors

V D Steen¹, R Ramsey-Goldman

Affiliation

¹ Department of Medicine, University of Pittsburgh School of Medicine, PA 15261.

PMID: 3134899
DOI: 10.1002/art.1780310716

Abstract

Phenothiazine-induced lupus with circulating anticoagulant (CAC) has been reported infrequently, and is rarely associated with significant symptoms. We describe a patient who we suspect had perphenazine-induced lupus erythematosus with CAC. She had recurrent episodes of venous thrombosis and ultimately developed superior vena cava syndrome. The relationships among phenothiazine-induced lupus, CAC, and thrombosis are discussed.

Publication types

Case Reports
Review

MeSH terms

Adult
Anorexia Nervosa / drug therapy
Blood Coagulation Factors / analysis
Blood Coagulation Factors / immunology
Cardiovascular Diseases / chemically induced
Depression / drug therapy
Female
Humans
Lupus Coagulation Inhibitor
Lupus Erythematosus, Systemic / blood
Lupus Erythematosus, Systemic / chemically induced*
Phenothiazines / adverse effects*
Phenothiazines / therapeutic use
Syndrome
Vena Cava, Superior*

Substances

Blood Coagulation Factors
Lupus Coagulation Inhibitor
Phenothiazines
phenothiazine