Abstract
The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Heterophile / biosynthesis
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Antibodies, Monoclonal / administration & dosage*
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Arthritis / immunology*
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Arthritis, Experimental / etiology
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Arthritis, Experimental / immunology*
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Arthritis, Experimental / therapy
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Autoantibodies / biosynthesis
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Collagen* / immunology
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Hypersensitivity, Delayed / etiology
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Immunoglobulin M / biosynthesis
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Immunosuppressive Agents / administration & dosage*
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Interleukin-2 / metabolism*
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Mice
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Mice, Inbred DBA
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Rats
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Receptors, Immunologic / immunology*
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Receptors, Interleukin-2
Substances
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Antibodies, Heterophile
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Antibodies, Monoclonal
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Autoantibodies
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Immunoglobulin M
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Immunosuppressive Agents
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Interleukin-2
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Receptors, Immunologic
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Receptors, Interleukin-2
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Collagen