Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction

Circulation. 2019 Jul 30;140(5):440-442. doi: 10.1161/CIRCULATIONAHA.118.039276. Epub 2019 Jul 29.

Qiying Fan¹, Hua Mao¹, Aude Angelini¹, Cristian Coarfa^{2

3}, Matthew J Robertson^{2

3}, William R Lagor⁴, Xander H T Wehrens^{1

4

5

6

7}, James F Martin^{4

8

9}, Xinchun Pi¹, Liang Xie¹

¹ Cardiovascular Research Institute, Department of Medicine (Q.F., H.M., A.A., X.H.T.W., X.P., L.X.), Baylor College of Medicine, Houston, TX.
² Departments of Molecular and Cellular Biology (C.C., M.J.R.), Baylor College of Medicine, Houston, TX.
³ Dan L. Duncan Comprehensive Cancer Center, Center for Precision Environmental Health (C.C., M.J.R.), Baylor College of Medicine, Houston, TX.
⁴ Department of Molecular Physiology and Biophysics (W.R.L., X.H.T.W., J.F.M.), Baylor College of Medicine, Houston, TX.
⁵ Cardiovascular Research Institute, Department of Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX.
⁶ Department of Pediatrics (X.H.T.W.), Baylor College of Medicine, Houston, TX.
⁷ Center for Space Medicine (X.H.T.W.), Baylor College of Medicine, Houston, TX.
⁸ Cardiovascular Research Institute, Program in Developmental Biology (J.F.M.), Baylor College of Medicine, Houston, TX.
⁹ The Texas Heart Institute, Houston (J.F.M.).

No abstract available

Keywords: cell proliferation; endothelial cells; heart failure; hypoxia; myocardial infarction; myocytes, cardiac; regeneration.

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