Reductive Coupling between C-N and C-O Electrophiles

J Am Chem Soc. 2019 Aug 14;141(32):12481-12486. doi: 10.1021/jacs.9b05224. Epub 2019 Aug 1.

Abstract

The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism.

Publication types

  • Research Support, Non-U.S. Gov't