Identification of a new allele, HLA-DRB1*01:01:01:02 discovered using third-generation sequencing

HLA. 2019 Nov;94(5):458-459. doi: 10.1111/tan.13650. Epub 2019 Aug 16.

Abstract

HLA-DRB1*01:01:01:02 is the first reported intronic variant of DRB1*01:01:01, differing by a single nucleotide substitution.

Keywords: HLA-DRB1; SMRT sequencing; genomic sequence; new allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Base Sequence
  • HLA-DRB1 Chains / genetics*
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Introns / genetics*
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA / methods*
  • Sequence Homology

Substances

  • HLA-DRB1 Chains
  • HLA-DRB1*01:01 antigen