On the Road to a HIV Cure: Moving Beyond Berlin and London

Infect Dis Clin North Am. 2019 Sep;33(3):857-868. doi: 10.1016/j.idc.2019.04.007.

Abstract

The Berlin patient, a famous example for human immunodeficiency virus (HIV) cure, had received a bone marrow transplantation with an HIV resistance mutation. The authors describe his case and others that had shown HIV control, like the Mississippi baby who was started on antiretroviral therapy very early after birth, and posttreatment controllers, like the VISCONTI cohort. Moreover, the authors outline various strategies, oftentimes informed by these individuals, that have been tried in vitro, in animal models, or in human trials, to deplete the latent reservoir, which is considered the basis of HIV persistence and the obstacle to cure.

Keywords: Broadly neutralizing antibodies (bNAbs); HIV; HIV cure; HIV persistence; HIV vaccine; Long-term remission; PTC; Posttreatment controllers.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Disease Resistance*
  • HIV / immunology*
  • HIV Infections / drug therapy*
  • HIV Infections / immunology*
  • Humans
  • Treatment Outcome

Substances

  • Anti-HIV Agents