Numerous factors affect reaction times to vibrotactile cues. Therefore, it is important to consider the relative magnitudes of these time delays when designing vibrotactile displays for real-time applications. The objectives of this study were to quantify reaction times to typical vibrotactile stimuli parameters through direct comparison within a single experimental setting, and to determine the relative importance of these factors on reaction times. Young (n = 10, 21.9 ± 1.3 yrs) and older adults (n = 13, 69.4 ± 5.0 yrs) performed simple reaction time tasks by responding to vibrotactile stimuli using a thumb trigger while frequency, location, auditory cues, number of tactors in the same location, and tactor type were varied. Participants also performed a secondary task in a subset of the trials. The factors investigated in this study affected reaction times by 20-300 ms (reaction time findings are noted in parentheses) depending on the specific stimuli condition. In general, auditory cues generated by the tactors (<20 ms), vibration frequency (<20 ms), number of tactors in the same location (<30 ms) and tactor type (<50 ms) had relatively small effects on reaction times, while stimulus location (20-120 ms) and secondary cognitive task (>130 ms) had relatively large effects. Factors affected young and older adults' reaction times in a similar manner, but with different magnitudes. These findings can inform the development of vibrotactile displays by enabling designers to directly compare the relative effects of key factors on reaction times.