"2-Amino glucose" as a substrate for synthesis of magnetically recoverable nanocatalyst NiFe2O4@SiO2@amino glucose for the green synthesis of novel bis (1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes

Carbohydr Res. 2019 Sep 1:483:107755. doi: 10.1016/j.carres.2019.107755. Epub 2019 Aug 3.

Abstract

2-Amino glucose ((2S,3R,4S,5S,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) as a substrate for the synthesis of NiFe2O4@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of bis(1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes through one-pot condensation of aldehyde or pyrazolo carbaldehyde and two equivalents of 4-hydroxyquinolin-2(1H)-ones in aqueous media. Eco-friendliness, high purity of the desired products, short reaction time and easy workup procedure can be mentioned as the other advantages of this method. The structures of the synthesized 4-hydroxy-2(1H)-quinolone compounds were confirmed by 1H, 13C NMR and FTIR spectral data and elemental analyses.

Keywords: 2-Amino glucose; 4-hydroxyquinoline; Bis(oxoquinolin-3-yl)methanes; Green chemistry; NiFe(2)O(4)@SiO(2)@amino glucose.

MeSH terms

  • Amino Sugars / chemistry*
  • Catalysis
  • Ferric Compounds / chemistry
  • Green Chemistry Technology
  • Metal Nanoparticles
  • Methane / chemistry*
  • Molecular Structure
  • Nickel / chemistry
  • Quinolones / chemical synthesis*
  • Quinolones / chemistry
  • Silicon Dioxide / chemistry

Substances

  • Amino Sugars
  • Ferric Compounds
  • Quinolones
  • nickel ferrite
  • Silicon Dioxide
  • Nickel
  • Methane