Transcriptome variation in human populations and its potential application in forensics

J Appl Genet. 2019 Nov;60(3-4):319-328. doi: 10.1007/s13353-019-00510-1. Epub 2019 Aug 10.

Abstract

This review presents the state-of-the-art in the forensic application of genetic methods driven by the research in population transcriptomics. In the first part of the review, the constraints of using classical genomic markers are shortly reviewed. In the second part, the developments in the field of inter-population diversity at the transcriptomic level are presented. Subsequently, a potential of population-specific transcriptomic markers in forensic science applications, including ascertaining population affiliation of human samples and cell mixtures separation, are presented.

Keywords: Forensic identification; Human population identification; Laser capture microdissection; Transcriptome variation.

Publication types

  • Review

MeSH terms

  • Cell Separation / methods
  • DNA Fingerprinting*
  • Forensic Sciences / trends*
  • Genetic Variation / genetics*
  • Humans
  • Transcriptome / genetics*