Autophagy in intracellular bacterial infection

Wei Hu; Hung Chan; Lan Lu; Kam Tak Wong; Sunny H Wong; Ming X Li; Zhan G Xiao; Chi H Cho; Tony Gin; Matthew T V Chan; William K K Wu; Lin Zhang

doi:10.1016/j.semcdb.2019.07.014

Autophagy in intracellular bacterial infection

Semin Cell Dev Biol. 2020 May:101:41-50. doi: 10.1016/j.semcdb.2019.07.014. Epub 2019 Sep 10.

Authors

Wei Hu¹, Hung Chan², Lan Lu³, Kam Tak Wong⁴, Sunny H Wong⁵, Ming X Li⁶, Zhan G Xiao⁶, Chi H Cho⁶, Tony Gin², Matthew T V Chan⁷, William K K Wu⁸, Lin Zhang⁹

Affiliations

¹ Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, PR China; Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
² Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
³ Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, Sichuan, PR China.
⁴ Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China.
⁵ Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, and Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China.
⁶ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, PR China.
⁷ Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: [email protected].
⁸ Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, and Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: [email protected].
⁹ Department of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, and Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: [email protected].

PMID: 31408699
DOI: 10.1016/j.semcdb.2019.07.014

Abstract

Autophagy is a conserved intracellular degradation process enclosing the bulk of cytosolic components for lysosomal degradation to maintain cellular homeostasis. Accumulating evidences showed that a specialized form of autophagy, known as xenophagy, could serve as an innate immune response to defend against pathogens invading inside the host cells. Correspondingly, infectious pathogens have developed a variety of strategies to disarm xenophagy, leading to a prolonged and persistent intracellular colonization. In this review, we first summarize the current knowledge about the general mechanisms of intracellular bacterial infections and xenophagy. We then focus on the ongoing battle between these two processes.

Keywords: Infection; Intracellular bacteria; Xenophagy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy / immunology*
Bacterial Infections / immunology*
Bacterial Infections / pathology
Humans
Immunity, Innate / immunology