A practical copper-catalyzed approach to β-lactams via radical carboamination of alkenyl carbonyl compounds

Chem Commun (Camb). 2019 Aug 29;55(71):10523-10526. doi: 10.1039/c9cc05668h.

Abstract

Functionalized β-lactams are highly important motifs in synthetic chemistry. We report an efficient and novel approach to the synthesis of β-lactams via a copper(i)-catalyzed cascade process involving C(benzyl)-H radical abstraction, intermolecular alkene addition, and intramolecular amination reaction. Variously substituted alkenes were synthesized from vinylacetic acid, leading to the corresponding β-lactams in moderate to good yields. Preliminary studies indicate that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle.