Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

PLoS Med. 2019 Aug 15;16(8):e1002882. doi: 10.1371/journal.pmed.1002882. eCollection 2019 Aug.

Abstract

Amita Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis prevention and treatment in pregnant women, children, and people with HIV.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Child
  • Clinical Trials as Topic / methods*
  • Coinfection / microbiology
  • Coinfection / virology
  • Female
  • HIV Infections / complications*
  • Humans
  • Lactation
  • Patient Selection*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / drug therapy*

Substances

  • Antitubercular Agents